Endocrine Abstracts

We present here a case of 70 year old female, seen in endocrine clinic for Hypothalamic-Pituitary-Adrenal (HPA) axis suppression after prolonged glucocorticoid use. History revealed that she had prolonged use of prednisolone for her asthma in the past. In 2011, Prednisolone was stopped but she had to be started on Hydrocortisone replacement due to HPA axis suppression. She was taking Hydrocortisone 20 mg BD. Trials to wean her off Hydrocortisone failed due to ongoing tiredness...

: In the present study we hypothesized that maternal thyroid disorders may be associated with maternal and foetal morbidity and mortality. The present study included 136 pregnant women selected randomly in first trimester and observed throughout the pregnancy till birth. The assessment of thyroid hormones showed a total of 33.08% (n=45) pregnant ladies were having thyroid disorders; 17.65% (n=24) with hypothyroidism and 15.44% (n=21) with hyperthyroi...

Introduction: Post-surgical hypoparathyroidism (PoSH) is common after thyroidectomy. Most cases recover within 6 months, but several require long-term supplementation with calcium and activated vitamin D. When PoSH persists beyond 6 months, it is considered to be ‘long-term’ or ‘permanent’. However, few studies have demonstrated recovery beyond this time period.Aim: Aim of this study is to determine the frequency of late recovery in t...

68 years old female initially referred to endocrine clinic in November 2016 for assessment of fluctuating thyroid function. She had a history of long standing primary hypothyroidism, stable on treatment with 100 mcg Levothyroxine. In last one year, Levothyroxine was tapered and stopped due to persistent suppression of TSH and high normal Free T4. Last tests showed TSH of <0.01mIU/l and Free T4 of 27.1 pmol/l. She had ongoing complaints of feeling increasingly tired and gen...

Toxic adenomas nodules rarely harbour cancer. Fine needle aspiration (FNA) is often not done due to the rarity of these lesions being cancer, the difficulty in interpreting cytology in hyperthyroid patients and the rarely reported instance of precipitating thyrotoxicosis. Here, we present two young Caucasian female patients with toxic adenomas, who underwent hemithyroidectomy and the histology unexpectedly revealed differentiated follicular cancer. The first is a 29-year-old p...

Introduction: The hyperparathyroidism-jaw tumour syndrome is a rare autosomal, dominantly inherited disorder characterized by neoplastic or cystic lesions in parathyroid gland, jaws and the kidneys. With approximately 200 reported cases in literature this condition remains a challenge both diagnostically and in guiding further management.Case report: Seventeen year old scholar was seen by the maxillofacial department at Medway Hospital with 2 painless sw...

Introduction: Covid -19 can cause serious or severe illness in anyone but those with chronic health conditions are at greater risk. Adrenal insufficiency (AI) is assumed to be associated with an increased Covid-19 infection risk, which could trigger an adrenal crisis. We conducted a retrospective study at district general hospital to assess the incidence of COVID-19 in Adrenal insufficiency patients.Method and material: Retrospective review of 43 patient...

Background: Obese individuals may perceive the taste of caloric dense food as less intense, resulting in decreased activation of the reward system. Preclinical research provides some insights into the role of GLP-1 in the gustatory coding. The impact of GLP-1 receptor agonists on the tongue and taste perception remains largely unaddressed in clinical settings.Aim: to investigate the impact of semaglutide on the tongue transcriptome, taste perception and ...

Case history: A 30-year-old Ugandan male, now living in UK, presented to A&E with confusion and agitation. Capillary blood glucose was 0.9 mmol/l and he was commenced on intravenous Dextrose. During blood donor screening in Uganda, he was told that he had a blood-borne infection. He had gross hepatomegaly on examination. During admission, he experienced repeated episodes of hypoglycaemia despite increased dietary intake of carbohydrates and continuous infusions of 5%-10% D...

Introduction: 99m/Tc-MIBI parathyroid scintigraphy (MIBI) is the most common test used for pre-operative localization of parathyroid adenoma in primary hyperparathyroidism. We evaluated the influence of serum calcium and parathyroid hormone (PTH) levels on sensitivity of MIBI imaging in successful parathyroid localisation in patients identified as having primary hyperparathyroidism.Methods and material: Retrospective review of 403 patients who had MIBI s...